Endocrine Abstracts

Introduction: Newly diagnosed type 1 diabetes is characterized by a transient partial remission period (‘honeymoon’), starting shortly after initiation of insulin treatment and during which the patient’s requirement for exogenous insulin treatment declines. Improvement of peripheral insulin sensitivity as well as a partial beta-cell recovery with improved insulin secretion was speculating to contribute to the pathogenesis of this phenomenon.<p class="abstext...

Introduction: Type 1 diabetes (T1DM) occurs as a result of autoimmune destruction of pancreatic β-cells which is supported by the presence of autoantibodies well before the onset of T1DM. Individuals at risk for T1DM are characterised by a deficient first-phase insulin response and impaired glucose tolerance which is present before the onset of T1DM.Case: We describe a case of 6 year-old asymptomatic girl who took part in the TrialNet Pathway-to-Pre...

Background: In the UK, Growth Hormone (GH) is indicated for treatment of children with short stature secondary to growth hormone deficiency (GHD), Prader Willi syndrome (PWS), Turner syndrome (TS), SHOX gene mutation, chronic renal insufficiency and born small for gestational age (SGA).Objectives: The aim was to assess the compliance of our local practice with the NICE guidance for GH therapy in children in addition to local guidance that TFTs and IGF-I ...

Introduction: It has been documented that autoimmune thyroiditis (AT) predisposes to the development of papillary thyroid cancer (PTC). The presence of chronic inflammation was thought to act as an initiating factor in carcinogenesis. Moreover elevated levels of TSH found in hypothyroid patients with AT were speculated to stimulate follicular epithelial proliferation and thereby promote the development of PCT.Case: We describe a case of two sisters aged ...